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The most impactful card is probably Exterminio, which would translate literally to Extermination but probably references to Overkill, the mechanic from Final Fantasy X, . Exterminio is a black instant removal spell with an interesting twist: setting a creature's health to -9999 plays around indestructible

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This puts a pretty clear ceiling on how much someone would be willing to pay for an individual card in the game

In Modern, its also found a home in the cascade decks like Living End and Temur Footfalls, as its a graveyard hate you can play without it getting in the way of cascading into your namesake card

When Disorienting Choice resolves, the next opponent in turn order that controls a permanent chosen with Disorienting Choice decides whether to exile that permanent