NRX-1532 building block NCCCCCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95%

NCCCCCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

378 SMILES [N-]=[N+]=NCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

91 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCN)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons

NRX-1532 building block NCCCCCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95%NRX 1532 is an enhancer of the interaction between beta catenin and beta TrCP. NRX 1532 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta catenin by the 26S proteasome. Product Name NRX 1532 Synonyms CAS Number n a Related CAS Molecular Formula C16H11F3N4O2 Molecular Weight 348. 285 SMILES FC(F)(F)C1=CC=C(C(=O)NC2=CC(=CC=C2)C2=CC=NN2)C(=O)N1 Purity (HPLC) >= 95% Physical Appearance White solid