NCT 02 Size:5mg 89 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

89 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

95 SMILES [O-]S(=O)(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S(=O)(=O)NCCOCCOCCOCCN=[N]#N Purity (HPLC) 95% Shipping Conditions Room Temperature Storage Conditions Refrigerated Regulatory Statemen: For Research Use Only

557 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name tert-butyl N-{2-[4-(3-aminopropyl)piperazin-1-yl]ethyl}carbamate Synonyms CAS Number 2719062-98-1 Related CAS Molecular Formula C14H30N4O2 Molecular Weight 286

73 SMILES: CCN(CC)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2S([O-])(=O)=O)S(=O)(=O)NCC#C)=[N+](CC)CC)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

NCT 02 Size:5mg 89 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)NCT02 is a molecular glue cyclin K degrader. NCT02 induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. Product Name NCT 02 Synonyms CAS Number 790245 61 3 Related CAS Molecular Formula C17H16N2O2S Molecular Weight 312. 39 SMILES CC1=CN=C(NC(=O)CC2=COC3=CC4=C(CCC4)C=C23)S1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO, DMF Shipping Conditions Room Temperature Storage