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JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM
Product Name DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C90H115FN10O25 Molecular Weight 1755
33 Purity (HPLC) >= 95% Solubility DMSO
455 SMILES OC(=O)CCCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name DOTA-tris(t-Bu)ester-butyne Synonyms CAS Number 2125661-54-1 Related CAS Molecular Formula C32H57N5O7 Molecular Weight 623
Azide-Propionyl-Val-Cit-PAB(m-PEG8) ca JTP-74057) is an orally activeSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned through selection
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