Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg Product Name Phthalimidinoglutarimide-C3-O-PEG2-OH Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG2-OH

Product Name Phthalimidinoglutarimide-C3-O-PEG2-OH Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG2-OH CAS Number n/a Related CAS Molecular Formula C20H26N2O6 Molecular Weight 390

peptides and proteins

Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500

0]non-4-yne) is a strained cyclooctyne used in click chemistry for copper-free bioconjugation reactions

Locally Advanced or Metastatic Breast Cancer

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg Product Name Phthalimidinoglutarimide-C3-O-PEG2-OH Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG2-OHSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly