Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg 701 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCOCCOCCOCCN=[N]#N)=[N+](C)C)=C1

701 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCOCCOCCOCCN=[N]#N)=[N+](C)C)=C1

Proteolysis targeting chimera (PROTAC) building block

S)-AHPC-CO-PEG6-OH Synonyms CAS Number n/a Related CAS Molecular Formula C35H54N4O10S Molecular Weight 722

the components of the reaction are bioinert

NRX-2663 is an enhancer of the interaction between beta-catenin and beta-TrCP

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg 701 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCOCCOCCOCCN=[N]#N)=[N+](C)C)=C1SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by