Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan dbco-hexanoyl [2H]C([2H])([2H])N(CCNC)C([2H])([2H])[2H] Purity (HPLC) >= 95%

[2H]C([2H])([2H])N(CCNC)C([2H])([2H])[2H] Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

366 SMILES OCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C63H91N9O17 Molecular Weight 1246

85 SMILES Cl

Product Name DOTA-tris(t-Bu)ester-PEG2-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C34H64N8O9 Molecular Weight 728

Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan dbco-hexanoyl [2H]C([2H])([2H])N(CCNC)C([2H])([2H])[2H] Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU