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Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates
Its fluorescence is relatively pH-insensitive
making it ideal for aqueous-based applications without requiring organic solvents
43 Purity (HPLC) >= 95% Physical Appearance Dark Solid Optical Properties Abs/Em Maxima: 494/585 nm Solubility DMSO
(1) Yamazoe
Propargy-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Size:25mg Linker substitution influences succinimide ringSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing
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