Just use the Actives Ability then retreat into the benched Greninja BREAK to finish it off
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Some examples: Swords to Plowshares, Teferis Protection, Chaos Warp, Great Train Heist (or other Spree cards, you pay extra costs but can go wild), Akromas Will, Deflecting Swat, Wear/Tear, and my personal favorite, Reprieve
One copy is the kind of card that can end the game if your draw it, but it might only work in certain situations
Shes got an intriguing you lose condition that seems very slow to pull off, especially given that she wants to shuffle back into your deck each time she exiles a creature and puts a hit counter on it