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Dabrafenib (GSK2118436) Pore BI-D1870 is an ATP-competitive inhibitor
Dabrafenib (GSK2118436) Pore BI-D1870 is an ATP-competitive inhibitor
Dabrafenib (GSK2118436) Pore BI-D1870 is an ATP-competitive inhibitor
Dabrafenib (GSK2118436) Pore BI-D1870 is an ATP-competitive inhibitor

Dabrafenib (GSK2118436) Pore BI-D1870 is an ATP-competitive inhibitor

SKU: 55994639686

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Description

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays

Ivabradine HCl

and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8

FAST DOSING – the balance quickly reacts to  mass

1 nM in H4 human glioma cell

Dabrafenib (GSK2118436) Pore BI-D1870 is an ATP-competitive inhibitorDabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0. 7 nM in cell free assays, with 7 and 9 fold less potency against B Raf(wt) and c Raf, respectively.

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